Paper Details
MUCOSAL DRUG DELIVERY : COMPREHENSIVE REVIEW
Authors
Gopal A.Chavhan, Nikita E. Bajad, Swati P.Deshmukh
Abstract
Mucosal drug delivery has emerged as a promising approach for administering therapeutic agents due to the extensive mucosal surface area and its potential for rapid and targeted absorption. It involves the administration of drugs via mucous membranes such as nasal, buccal, pulmonary, vaginal, and gastrointestinal routes. This method can enhance drug bioavailability, minimize systemic side effects, and improve patient compliance compared to traditional delivery systems. Advances in nanotechnology, formulation strategies, and mucoadhesive materials have significantly enhanced the efficacy of mucosal drug delivery by overcoming barriers such as enzymatic degradation and rapid mucociliary clearance. Innovative strategies, including nanoparticle-based systems, hydrogels, and bio adhesive microspheres, have demonstrated potential for controlled and sustained drug release. Additionally, the mucosal immune system offers an opportunity for localized vaccine delivery and immunotherapy. However, challenges remain, such as drug permeability limitations, variability in mucosal properties, and formulation stability. This review discusses the current progress, challenges, and future prospects in the field, highlighting novel technologies that could transform mucosal drug delivery into a mainstream therapeutic modality.
Keywords
Mucosal Routes of Administration, Drug Formulation and Carriers, Mucoadhesion, Permeation Enhancers, Barriers to Mucosal Drug Delivery, Drug Release Mechanisms
Citation
MUCOSAL DRUG DELIVERY : COMPREHENSIVE REVIEW. Gopal A.Chavhan, Nikita E. Bajad, Swati P.Deshmukh. 2025. IJIRCT, Volume 11, Issue 1. Pages 1-10. https://www.ijirct.org/viewPaper.php?paperId=2501024