Therapeutic Targets and Challenges During Delivery of Drugs Used In Alzheimer’s Disease

Authors

Prajval V. Tidke, Dr. Asawali R. Pawar, Dr. Swati P. Deshmukh

Abstract

Alzheimer's disease is most common cause of dementia. The pathophysiology of Alzheimer’s disease includes the presence of extracellular plaques of insoluble β-amyloid peptide (αβ) and neurofibrillary tangles (NFT) of P-tau in neuronal cytoplasm. Due to this β-amyloidal plaques and neurofibrillary tangles formation it will damage the neurons and synapses which is involved in memory process can be affected. So, in this review article we will discuss about different therapeutic Targeted for Alzheimer's Disease like anti-amyloidal approaches, anti-tau approaches, acetylcholinesterase inhibitors, glutamatergic system modifiers, immunotherapy, anti-inflammatory targets, antioxidants, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors, insulin. There are different Challenge in the Delivery Drugs for Alzheimer's Disease. Also, there are different drug delivery strategies by oral, transdermal, intravenous, intranasal and other miscellaneous route which ultimately leading to Alzheimer’s disease cure. By this review we will get better understanding of Alzheimer’s disease pathophysiology, therapeutic targets and drug delivery systems towards better delivery of anti-Alzheimer actives.

Keywords

Neurofibrillary tangles, Alzheimer’s disease, Dementia, Amyloid β, Tau, Neurodegeneration.

Therapeutic Targets and Challenges During Delivery of Drugs Used In Alzheimer’s Disease. Prajval V. Tidke, Dr. Asawali R. Pawar, Dr. Swati P. Deshmukh. 2025. IJIRCT, Volume 11, Issue 1. Pages 1-7. https://www.ijirct.org/viewPaper.php?paperId=2501022