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Publication Number

2407105

 

Page Numbers

1-5

Paper Details

A Comparative In Vitro Evaluation of Different Brands of Nimesulide Tablets

Authors

Roshan V. Jaiswal, Prashant Nalinde, Dr. Swati P. Deshmukh

Abstract

Five Indian Brands (coded as A,B,C,D,E) of 100 mg Nimesulide tablets were evaluated for various In vitro parameters, i.e. size and shape, uniformity of weight, hardness, friability, content, disintegration time and dissolution profile. All the products met the requirements of British Pharmacopoeia for tablet formulation. The hardness of all the brands was found to be in the range of 4.2-4.4 kg, while friability was less than 1 %. The disintegration time of all brands was found to be in the range of 2min 22 sec to 5min 29 sec. All brands comply the B.P weight variation test while brands A, B, C and D comply the B.P dissolution test except brand E. Formulation additives in the tablet, physical form of the drug used in the tablet and manufacturing process vary from manufacturer to manufacturer which is responsible for the variation in the observed dissolution profiles.

Keywords

Nimesulide in tablets, hardness, disintegration time, dissolution rate, quality evaluation.

 

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Citation

A Comparative In Vitro Evaluation of Different Brands of Nimesulide Tablets. Roshan V. Jaiswal, Prashant Nalinde, Dr. Swati P. Deshmukh. 2024. IJIRCT, Volume 10, Issue 4. Pages 1-5. https://www.ijirct.org/viewPaper.php?paperId=2407105

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