Neuroprotective potential of Phyllanthus niruri on diazepam induced amnesia in mice

Authors

Jayesh H. Lahoti, Anjali M. Wankhade, Vivek Paithankar, J.V. Vyas

Abstract

Phyllanthus niruri is a traditional medicinal plant used for the treatment of diseases such as kidney stone, inflammation in South east Asian countries. This study was carried out to evaluate the potential neuroprotection effect of the methanolic extract of the leaves of Phyllanthus niruri against diazepam-induced amnesia in mice. Thirty adult male mice were distributed into five groups: the two test groups received methanolic extract of leaves of Phyllanthus niruri (200, and 400 mg/kg), the normal control group received saline water, a positive control group received donepezil (5 mg/kg), and the negative control received diazepam (1.75 mg/kg). Learning and memory were evaluated using the Elevated plus maze apparatus . Statistical analyses were performed using one-way ANOVA followed by Dunnett’s test. Phyllanthus niruri leaves methanolic extract decreased the transfer latency time in amnesic mice evaluated in the elevated plus maze. These results suggest that the methanolic extract of Phyllanthus niruri leaves may possess antioxidant potential and might provide an opportunity for the management of neurological abnormalities in amnesic conditions.

Keywords

Amnesia . Benzodiazepine . Bacopa monniera . Cholinergic . Diazepam . GABAergic .Elevated Plus Maze

Neuroprotective potential of Phyllanthus niruri on diazepam induced amnesia in mice. Jayesh H. Lahoti, Anjali M. Wankhade, Vivek Paithankar, J.V. Vyas. 2024. IJIRCT, Volume 10, Issue 3. Pages 1-8. https://www.ijirct.org/viewPaper.php?paperId=2405053