To Study The Effect Of Lycopersicon Esculentum Leaves Extract On Alloxan Induced Diabetes On Experimental Animals
Author(s): Shreyash Bale, J.V. Vyas, Dr. V.V. Paithankar, Dr. A.W. Wankhade
Publication #: 2405052
Date of Publication: 26.05.2024
Country: India
Pages: 1-10
Published In: Volume 10 Issue 3 May-2024
Abstract
Lycopersicon esculentum (family: Solanaceae) commonly known as ‘Tomato’ widely used in traditional system of medicine for the treatment of diabetes mellitus. In the present study, methanol extract of Lycopersicon esculentum (MELE) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity on blood glucose level in alloxan induced diabetic rats. MELE (200 and 400 mg/kg) and metformin (250 mg/kg) were administered orally in alloxan (100 mg/kg, i.p.) induced diabetic rats. MELE (400 mg/kg) was found to have significant (p<0.001) blood glucose lowering effect. Preliminary Phytochemical investigation revealed the presence of alkaloids, phenolics, flavonoids, saponins and tannins as the major constituents in the ethanol extract. These results suggest that MELE (400 mg/kg) showed antihyperglycemic activity in alloxan induced diabetic rats.
Keywords: Lycopersicon esculentum, Leaves, Alloxan, Metformin, Antidiabetic activity
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