Paper Details
To Study The Effect Of Lycopersicon Esculentum Leaves Extract On Alloxan Induced Diabetes On Experimental Animals
Authors
Shreyash Bale, J.V. Vyas, Dr. V.V. Paithankar, Dr. A.W. Wankhade
Abstract
Lycopersicon esculentum (family: Solanaceae) commonly known as ‘Tomato’ widely used in traditional system of medicine for the treatment of diabetes mellitus. In the present study, methanol extract of Lycopersicon esculentum (MELE) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity on blood glucose level in alloxan induced diabetic rats. MELE (200 and 400 mg/kg) and metformin (250 mg/kg) were administered orally in alloxan (100 mg/kg, i.p.) induced diabetic rats. MELE (400 mg/kg) was found to have significant (p<0.001) blood glucose lowering effect. Preliminary Phytochemical investigation revealed the presence of alkaloids, phenolics, flavonoids, saponins and tannins as the major constituents in the ethanol extract. These results suggest that MELE (400 mg/kg) showed antihyperglycemic activity in alloxan induced diabetic rats.
Keywords
Lycopersicon esculentum, Leaves, Alloxan, Metformin, Antidiabetic activity
Citation
To Study The Effect Of Lycopersicon Esculentum Leaves Extract On Alloxan Induced Diabetes On Experimental Animals. Shreyash Bale, J.V. Vyas, Dr. V.V. Paithankar, Dr. A.W. Wankhade. 2024. IJIRCT, Volume 10, Issue 3. Pages 1-10. https://www.ijirct.org/viewPaper.php?paperId=2405052