Paper Details
Bauhinia Tomentosa L. A Potential Nephroprotective Agent Against Vancomycin- Induced Nephrotoxicity
Authors
Chetana P. Dakhare, Anjali M. Wankhade, J.V. Vyas, V.V. Paithankar
Abstract
Background: Vancomycin, a glycopeptide antibiotic, is widely used for the treatment of serious Gram-positive infections. However, its clinical use is often limited by nephrotoxicity, a significant adverse effect. This study investigates the nephroprotective potential of Bauhinia tomentosa, a medicinal plant traditionally used for its anti-inflammatory and antioxidant properties, against vancomycin-induced nephrotoxicity. Experimental nephrotoxicity was induced in laboratory animals through administration of vancomycin. The protective effect of Bauhinia tomentosa extract was assessed by evaluating various general parameters of kidney function and abnormal constituents in urine. Results demonstrated that Bauhinia tomentosa extract significantly ameliorated vancomycin-induced renal damage, as evidenced by improved kidney function and reduced the abnormal constituents in urine. These findings suggest that Bauhinia tomentosa possesses nephroprotective properties and may be a potential therapeutic agent to mitigate vancomycin-induced nephrotoxicity.
Aim and objectives: To evaluate the effect of Nephroprotective Bauhinia tomentosa L. roots on Vancomycin induced nephrotoxicity.
Materials and methods: VCM is used for inducing Nephrotoxicity and general parameters and qualitative analysis of abnormal constituents of urine was used to evaluate the results.
Result: There was statistically significant (P<0.001) association observed between ethanolic extract of Bauhinia tomentosa L. roots with nephrotoxicity induced by Vancomycin.
Conclusion: Evaluation of general parameters on nephrotoxicity in rats with Bauhinia tomentosa L. showed significantly increased body weight, kidney weight and urine volume significantly reduce increased general parameters which supports its Nephroprotective activity.
Keywords
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Citation
Bauhinia Tomentosa L. A Potential Nephroprotective Agent Against Vancomycin- Induced Nephrotoxicity. Chetana P. Dakhare, Anjali M. Wankhade, J.V. Vyas, V.V. Paithankar. 2024. IJIRCT, Volume 10, Issue 3. Pages 1-9. https://www.ijirct.org/viewPaper.php?paperId=2405050