Paper Details
Investigating The Protective Role of Brassica Juncea Extract Against Ibuprofen-Associated Liver Damage In Rats
Authors
Ratikesh A. Wawarkar, Amol Bondre, Poonam Bihone, Rajesh Mujariya, Manjeet Singh
Abstract
Hepatoprotective activity of the ethanolic of brassica juncea was studied in Wistar rats using the ethanol-induced liver hepatotoxicty. Ethanol administration resulted in significant elevation of physical parameters (Viz. rat liver weight and liver volume), biochemical parameters like (Viz. serum aspirate transaminase (AST); alanine transminase (ALT); alkaline phasphatase (ALP); direct bilirubin and total bilirubin levels, while albumin and total protein were found to be decreased compared to normal group). Pretreatment with silymarin, ethanolic extract of brassica juncea significantly prevented the physical and biochemical changes induced by these hepatotoxins. Histopathology of liver confirmed our finding as the treatment with the extracts resulted in minor liver cell damage compared to toxic control group.
Keywords
Biochemical parameters, Hepatoprotective, Alcoholic Liver Diseases (ALD), Ethanol.
Citation
Investigating The Protective Role of Brassica Juncea Extract Against Ibuprofen-Associated Liver Damage In Rats. Ratikesh A. Wawarkar, Amol Bondre, Poonam Bihone, Rajesh Mujariya, Manjeet Singh. 2024. IJIRCT, Volume 10, Issue 3. Pages 1-12. https://www.ijirct.org/viewPaper.php?paperId=2405027